Two mutations giving low-level streptomycin resistance inEscherichia coliK12
نویسندگان
چکیده
منابع مشابه
Mutations in gidB confer low-level streptomycin resistance in Mycobacterium tuberculosis.
The global threat posed by drug-resistant strains of Mycobacterium tuberculosis demands a greater understanding of the genetic basis and molecular mechanisms that govern how such strains develop resistance against various antituberculous drugs. In this report, we examine a new genetic basis for resistance to one of the oldest and most widely used second-line drugs employed in tuberculosis thera...
متن کاملMutations in Streptomycin Resistance Genes and Their Relationship to Streptomycin Resistance and Lineage of Mycobacterium tuberculosis Thai Isolates
BACKGROUND Streptomycin (SM) is recommended by the World Health Organization (WHO) as a part of standard regimens for retreating multidrug-resistant tuberculosis (MDR-TB) cases. The incidence of MDR-TB in retreatment cases was 19% in Thailand. To date, information on SM resistance (SMR) gene mutations correlated to the SMR of Mycobacterium tuberculosis Thai isolates is limited. In this study, t...
متن کاملUNIPARENTAL INHERITANCE FOR HIGH LEVEL STREPTOMYCIN RESISTANCE IN CHLAMYDOMONAS REINHARDIl
WO different classes of mutation to streptomycin resistance have been deTscribed in Chlamydomonas reinhardi (SAGER 1954, 1960; GILLHAM and LEVINE 1962). The first, sr-I, is resistant to 50 pg of streptomycin sulfate per ml under the experimental conditions to be reported here. These mutants segregate 1: 1 in crosses to wild type (ss) , The sr-1 mutants are all closely linked or allelic and lie ...
متن کاملStreptomycin resistance in a streptomycin-producing microorganism.
Cell-free extracts of Streptomyces bikiniensis contain an adenosine 5'-triphosphate-dependent kinase which inactivates streptomycin (Sm) and dihydrostreptomycin by phosphorylation. The products have been identified as streptomycin 6-phosphate and dihydrostreptomycin 6-phosphate. Activity was not present in logarithmic-phase cells, which were susceptible to 25 mug of Sm per ml. In stationary-pha...
متن کاملResistance factor-mediated streptomycin resistance.
Resistance (R) factor-mediated streptomycin (Sm) resistance differs from classical, high-level, chromosome-borne Sm resistance in its dominance over sensitivity and in the level of its effectiveness (in Escherichia coli approximately 25 mug/ml versus >2,000 mug/ml). In addition, an R factor-containing strain, unlike high-level Sm-resistant bacteria, showed an inoculum effect with respect to its...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 1970
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672300002640